Pure Glycine
Do you want to support high-quality sleep, recovery, connective tissue health, antioxidant protection, detoxification, and metabolic health – while also taking a step toward longevity?
Longelite Pure Glycine is a pure, science-backed tool for everyday care of both body and brain – safe and exceptionally effective. Designed for health today and ten years from now.
Package: 500 grams (powder)
Dietary supplement
| Category: | Anti-aging & Longevity |
|---|---|
| EAN: | 0788792005778 |
What is Longelite Pure Glycine?
Longelite Pure Glycine is a highly pure form of the non-essential amino acid glycine, which performs a number of key functions in the human body. Glycine supports high-quality sleep, stimulates collagen production and glutathione synthesis, and is essential for proper nervous system function. Many people have insufficient glycine intake because the modern Western diet tends to be low in glycine, which can have negative consequences for long-term health. Glycine is among the most multifunctional and well-researched compounds with significant potential to extend healthspan while also improving quality of life, especially in later years.
Ingredients and active compounds
Ingredients: 100 % glycine
Active compounds per daily dose 15 g:
| Compound | Amount |
|---|---|
| Glycine | 15 g |
Key active compounds
Glycine
Glycine is a simple yet biologically exceptionally important amino acid that is involved in a wide range of processes in the human body
Why Glycine?
Glycine is a simple yet biologically exceptionally important amino acid that is involved in a wide range of processes in the human body:
- It is a key building block of collagen – the most abundant protein in the body, essential for the health of skin, joints, bones, blood vessels, and all connective tissues,
- it is also a precursor of glutathione, the main cellular antioxidant, which protects cells from oxidative stress and supports detoxification of certain toxic substances,
- it acts as an inhibitory neurotransmitter in the central nervous system, where it contributes to calming neural activity, improves sleep quality, and reduces anxiety,
- it participates in glucose and homocysteine metabolism, and can therefore positively influence cardiometabolic health
- it regulates immune and inflammatory responses in the body.
More recent research also suggests its role in the regulation of circadian rhythms, thermoregulation, and cellular energy metabolism. Thanks to this exceptional multifunctionality, glycine is increasingly being studied as a potential tool for healthy aging and lifespan extension.
Main effects according to research:
✔ Sleep and recovery – Glycine supports the natural drop in body temperature before falling asleep, which is crucial for the onset of high-quality sleep. Human clinical studies have shown that glycine supplementation can improve both subjective and objective sleep quality, increase the proportion of deep (slow-wave) sleep, shorten the time needed to fall asleep, and at the same time improve morning alertness and reduce daytime sleepiness – all without a sedative effect.
Study: PMID: 22293292; https://doi.org/10.1111/j.1479-8425.2007.00262.x;
DOI:10.1111/j.1479-8425.2007.00262.x;
✔ Glutathione production – together with cysteine and glutamate, glycine forms the tripeptide glutathione – the most important endogenous antioxidant in the human body. Glutathione neutralizes free radicals, regenerates other antioxidants, and participates in detoxification of toxic substances in the liver. With increasing age, glutathione levels decline, leading to increased oxidative burden, metabolic disturbances, and greater susceptibility to chronic diseases and aging. Research shows that glycine supplementation (especially in combination with N-acetylcysteine) can effectively compensate for this decline – it increases glutathione levels, reduces oxidative stress, improves insulin sensitivity, inflammatory markers, and mitochondrial function. This combination has also been shown to extend lifespan in model organisms and improve multiple health parameters as well as physical and cognitive performance in humans.
Selected studies: PMID: 35975308; 37237908; 33783984; 21795440; 35268089; 29559876
✔ Collagen synthesis – glycine makes up approximately one third of all amino acids in collagen and is its key structural element. The availability of free glycine limits the speed and efficiency of collagen synthesis, especially under increased demand (e.g., tissue repair, aging, inflammation, athletic performance). Glycine is not only a passive building block– in some studies it also shows stimulatory effects on collagen gene expression. In preclinical and clinical studies, glycine supplementation has proven to be an effective way to support collagen production and improve the function and appearance of connective tissues, including the skin.
PMID: 20093739; 39453231; 30322002; https://doi.org/10.1016/j.biosystems.2023.105004
✔ Metabolic health – glycine is not only a structural amino acid, but also an active metabolic regulator. Studies have repeatedly shown that low plasma glycine levels are associated with a higher prevalence of insulin resistance, type 2 diabetes, and chronic inflammation. Glycine supplementation may have a positive effect on insulin sensitivity and other parameters of metabolic health and reduce inflammatory markers.
Selected studies: PMID: 29094215; 23615880; 28323968; 32093879; 38191455
✔ Longevity – glycine is among the most promising molecules with the potential to extend lifespan and preserve its quality for longer. In experimental studies, glycine supplementation extended lifespan in model organisms and at the same time improved metabolic and cognitive health in old age. In humans, studies suggest positive effects across many areas of health, especially in later life. Glycine participates in a vast number of processes in the body, and a growing body of evidence indicates that sufficient glycine intake may lead to slower biological aging, and therefore a lower risk of chronic diseases and a slower age-related decline in organ function.
PMID: 30916479; 39453231; 33783984; 37004845; 19864106
What does science say?
“Glycine is considered a promising geroprotective molecule – i.e., a compound that can slow processes of biological aging. Its beneficial effect on longevity is supported by several independent mechanistic and clinical studies. It increases the level of glutathione, the main intracellular antioxidant and an important detoxification molecule. With increasing age, glutathione levels decline, leading to increased oxidative stress, mitochondrial dysfunction, chronic inflammation, and faster biological aging, and it reduces chronic inflammation and endothelial dysfunction. Glycine has anti-inflammatory effects through activation of glycine receptors, inhibition of pro-inflammatory signaling pathways (e.g., NF-κB), and also indirectly through glutathione production and mitochondrial health. Glycine stimulates collagen synthesis and serves as a building block. Glycine makes up to 1/3 of amino acids in collagen, and its availability limits the rate of its synthesis, especially in old age. Glycine supplementation stimulates new collagen formation, which improves skin elasticity, joint health, vessel wall integrity, and other connective tissues. It counterbalances the negatives of excess methionine. Methionine is an essential amino acid that is key for growth and protein synthesis, but in excess it can accelerate aging, increase IGF-1 levels, and visceral fat. Dietary methionine restriction is one of the most robust nutritional interventions extending lifespan in model organisms, and glycine can mimic the effects of methionine restriction. Today’s modern diet is rich in methionine and poor in glycine, and therefore glycine may act protectively against the negative effects of excess methionine in the diet. It influences epigenetic regulation of aging-related genes. Glycine participates in methylation cycle processes, and research shows that it can affect epigenetic pathways and DNA methylation. Glycine deficiency (or methionine excess) can disrupt the methylation cycle and reduce the capacity of cells to maintain stable epigenetic marks – which is considered one of the key mechanisms of biological aging. It improves metabolic health and insulin sensitivity. Low plasma glycine levels are associated with a higher incidence of insulin resistance, type 2 diabetes, and chronic inflammation. Glycine supplementation can have a positive effect on insulin sensitivity and other parameters of metabolic health and reduce inflammatory markers.
Adequate glycine intake is especially important in later life, when many changes occur that glycine supplementation can partially compensate for, representing a safe, science-based approach to supporting long-term health and longevity."
Mgr. et Bc. František Knobloch
Molecular biologist and longevity specialist
Glycine
It is a pure, science-backed tool for everyday care of both body and brain – safe and exceptionally effective. Designed for health today and ten years from now.
How to take Glycine?
- Recommended daily dose: 15 g (equals 2 scoops leveled slightly below the rim), the dose can be divided into 2–3 smaller portions during the day
- Dosage: 3-5 g 1 – 3 x daily, depending on purpose, needs, and the overall context of diet and lifestyle
- Form: powder soluble in water – neutral mildly sweet taste, very well tolerated.
- Time of day: in the evening before sleep (to support sleep) or divided with main meals during the day.
- With what: can be taken on an empty stomach or with food.
- Preparation instructions: Dissolve two scoops leveled slightly below the rim in 200 ml of water and drink.
Warnings
-
Do not exceed the recommended daily dose. It is not a substitute for a varied and balanced diet. Keep out of reach of children. Not intended for children, pregnant or breastfeeding women. Store in a well-sealed container, in a dry and dark place.
Who is it not recommended for?
This product is not recommended for:
- people with severe renal insufficiency (due to possible burden from nitrogen metabolites),
- children without professional supervision,
- people with metabolic disorders of glycine metabolism (rare)
In other cases, glycine is very safe – clinical studies have tested doses up to 15 g daily without any adverse effects.
Manufacturer
all4longevity labs, s. r. o., Vinohradská 938/37, 120 00 Prague 2, Czech Republic
List of discussions
Pure Glycine
Renata Rektoříková
Tým Longelite
Fermentace
Ivana
Tým Longelite